Peripheral Inflammatory Biomarkers vs. Suicide Risk in Major Depression (2025 Study)

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Introduction Major depressive disorder (MDD) is a complex, heterogeneous psychiatric condition often accompanied by increased risk for suicidal behavior. Understanding biological markers that can predict or elucidate suicide risk is a high priority in psychiatry. Over the past decade, research has increasingly focused on the role of immune dysregulation, particularly peripheral inflammatory biomarkers, in depression […]

Anti-clotting drugs: Not as good as angioplasty?

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When it comes to treating coronary artery disease (CAD) and related heart conditions, both anti-clotting medications and angioplasty are vital tools. However, they serve different purposes, and their effectiveness depends on the specific clinical scenario. Understanding the Treatments Anti-Clotting Drugs (Anticoagulants and Antiplatelet Agents) Purpose:These medications prevent the formation of blood clots that can block […]

How Using Opioids for Acute Pain is Like Burning Coal for Energy

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Introduction Throughout history, humanity has sought efficient and accessible sources of energy to power societies, fuel industry, and improve living standards. Coal, for centuries, has been a primary energy source—abundant, reliable, and inexpensive—yet its environmental and health costs have grown increasingly apparent. Similarly, in medicine, opioids have long been the mainstay for managing acute pain—widely […]

PCMH Fails Natural Experiment

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Introduction The Patient-Centered Medical Home (PCMH) model has been heralded as a transformative approach to primary care, emphasizing comprehensive, coordinated, accessible, and patient-centered services. Launched to improve quality, reduce costs, and enhance patient experience, the PCMH concept has garnered significant policy and financial support. However, empirical evaluations reveal mixed or disappointing results, raising questions about […]

UDHPs Enable New Ecosystems & Strategic Partnerships

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Introduction In the rapidly evolving digital landscape, organizations are continually seeking innovative ways to enhance their competitiveness, expand their market reach, and foster collaborative growth. One of the transformative developments in recent years has been the advent of User-Driven Hybrid Platforms (UDHPs). These platforms are reshaping business ecosystems by enabling new forms of collaboration, fostering […]

Mayo Clinic Platform: Healthcare platforms and AI

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Introduction The landscape of healthcare is rapidly evolving, driven by technological advancements, digital transformation, and an increasing emphasis on personalized medicine. Among the pioneers leading this transformation is the Mayo Clinic, renowned for its patient-centered approach and innovative research. The Mayo Clinic Platform (MCP) represents a strategic initiative to harness the power of digital health […]

The World’s Psychoactive Drug of Choice

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Introduction Throughout human history, substances that alter mental states—psychoactive drugs—have played a complex role in societies worldwide. From ancient rituals to modern recreational use, psychoactive substances have been intertwined with culture, religion, medicine, and social behaviors. Today, the global landscape of psychoactive drug use is vast and multifaceted, encompassing legal and illegal substances, traditional and […]

How Health Systems are Losing Contact with their Clinicians

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Introduction The relationship between health systems and their clinicians is foundational to effective, patient-centered care. Clinicians—doctors, nurses, allied health professionals—are the frontline providers who translate policies, protocols, and organizational goals into tangible patient outcomes. When this relationship is strong, health systems benefit from motivated staff, high-quality care, and better patient satisfaction. However, in recent years, […]

Tom Knight, HealthcareDiversion.org

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Introduction Healthcare diversion is a complex and pressing issue that affects communities, law enforcement, healthcare institutions, and public health at large. It involves the illegal and often dangerous practice of redirecting prescription drugs, especially controlled substances like opioids, from legitimate medical channels into illicit markets. This practice fuels the ongoing opioid epidemic, contributes to drug […]